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Record W4412894090 · doi:10.70962/jhi.20250015

Characterization of the first patient with disseminated coccidioidomycosis and autosomal dominant STAT1 deficiency

2025· article· en· W4412894090 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueJournal of Human Immunity · 2025
Typearticle
Languageen
FieldMedicine
TopicFungal Infections and Studies
Canadian institutionsHospital for Sick Children
FundersNational Center for Advancing Translational SciencesNational Center for Research ResourcesNational Institutes of HealthNarodowe Centrum Badań i RozwojuAgence Nationale de la RechercheInstitut National de la Santé et de la Recherche MédicaleNational Institute of Allergy and Infectious DiseasesRockefeller UniversitySt. Giles Foundation
KeywordsMedicineImmunology

Abstract

fetched live from OpenAlex

A heterozygous STAT1 mutation (K410E) was identified in a child with disseminated coccidioidomycosis. This report highlights the critical role of IFN-γ–mediated immunity in controlling fungal infections and expands the known phenotypic spectrum of autosomal dominant STAT1 deficiency.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.628
Threshold uncertainty score0.255

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.244
Teacher spread0.237 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it