Evolutionarily divergent nidovirus with an exceptionally large genome identified in Pacific oysters undergoing mass mortality
Bibliographic record
Abstract
Metatranscriptomic data from a mass-mortality event of adult Pacific Oysters, Crassostrea ( Magallana ) gigas , the most widely cultivated shellfish globally, revealed a nidovirus shown to replicate in a bivalve, Pacific Oyster Nidovirus 1 (PONV1). At 64,331 bp of linear bisegmented, positive-sense single-stranded RNA, PONV1 has one of the largest genomes reported for an RNA virus. Moreover, transcriptomic data reveal that many conspecific viruses of PONV1 occur in Pacific oysters from Europe and the Pacific coasts of Asia and North America. PONV1 (tentative species Megarnavirus gigas ) and its conspecific viruses represent a putative family, Megarnaviridae , that is widely divergent from other families of nidoviruses, and encodes protein domains likely involved in virus–host interaction that are undescribed for other nidoviruses. Given that PONV1 occurs in diseased Pacific oysters undergoing mass mortality, and that close relatives of PONV1 are widespread globally, it emphasizes the need for caution in the translocation of Pacific oyster spat that routinely occurs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".