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Record W4413001500 · doi:10.1016/j.bbamem.2025.184436

Two phase coexistence in ternary mixtures of saturated and polyunsaturated phosphatidylcholines with cholesterol

2025· review· en· W4413001500 on OpenAlexafffund
James H. Davis

Bibliographic record

VenueBiochimica et Biophysica Acta (BBA) - Biomembranes · 2025
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicLipid Membrane Structure and Behavior
Canadian institutionsUniversity of Guelph
FundersOntario Ministry of Research and InnovationNatural Sciences and Engineering Research Council of CanadaCanada Foundation for Innovation
KeywordsDegree of unsaturationPhosphatidylcholineTernary operationPhase (matter)ChemistryAtmospheric temperature rangeChromatographyAnalytical Chemistry (journal)PhospholipidThermodynamicsOrganic chemistryBiochemistryMembrane

Abstract

fetched live from OpenAlex

Combining 2 H and 14 N nuclear magnetic resonance measurements on ternary lipid/cholesterol mixtures it is possible to quantitate the phase separation into coexisting ℓ o and ℓ d domains using a single sample whose composition is within the two phase region. Mixtures of each of the unsaturated phospholipids dioleoyl phosphatidylcholine, dilinoleoyl phosphatidylcholine and dilinolenoyl phosphatidylcholine with the saturated dipalmitoyl phosphatidylcholine and cholesterol all exhibit ℓ o and ℓ d phase coexistence over a substantial range of compositions and temperatures. A higher degree of unsaturation broadens the temperature range of two phase coexistence and results in the ℓ d phase domains actually being significantly more ‘fluid’ at lower temperatures than they are at higher temperatures.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.002
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.332
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes2
Has abstractyes

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Same venueBiochimica et Biophysica Acta (BBA) - BiomembranesSame topicLipid Membrane Structure and BehaviorFrench-language works237,207