Exploration of Fully‐Automated Body Composition Analysis Using Routine CT‐Staging of Lung Cancer Patients for Survival Prognosis
Bibliographic record
Abstract
BACKGROUND: AI-driven automated body composition analysis (BCA) may provide quantitative prognostic biomarkers derived from routine staging CTs. This two-centre study evaluates the prognostic value of these volumetric markers for overall survival in lung cancer patients. METHODS: Lung cancer cohorts from Hospital A (n = 3345, median age 65, 86% NSCLC, 40% M1, 40% female) and B (n = 1364, median age 66, 87% NSCLC, 37% M1, 38% female) underwent automated BCA of abdominal CTs ±60 days of primary diagnosis. A deep learning network segmented muscle, bone and adipose tissues (visceral = VAT, subcutaneous = SAT, intra-/intermuscular = IMAT and total = TAT) to derive three markers: Sarcopenia Index (SI = Muscle/Bone), Myosteatotic Fat Index (MFI = IMAT/TAT) and Abdominal Fat Index (AFI = VAT/SAT). Kaplan-Meier survival analysis, Cox proportional hazards modelling and machine learning-based survival prediction were performed. A survival model including clinical data (BMI, ECOG, L3-SMI, -SATI, -VATI and -IMATI) was fitted on Hospital A data and validated on Hospital B data. RESULTS: In nonmetastatic NSCLC, high SI predicted longer survival across centres for males (Hospital A: 24.6 vs. 46.0 months; Hospital B: 13.3 vs. 28.9 months; both p < 0.001) and females (Hospital A: 37.9 vs. 53.6 months, p = 0.008; Hospital B: 23.0 vs. 28.6 months, p = 0.018). High MFI indicated reduced survival in males at both hospitals (Hospital A: 43.7 vs. 28.2 months; Hospital B: 28.8 vs. 14.3 months; both p ≤ 0.001) but showed center-dependent effects in females (significant only in Hospital A, p < 0.01). In metastatic disease, SI remained prognostic for males at both centres (p < 0.05), while MFI was significant only in Hospital A (p ≤ 0.001) and AFI only in Hospital B (p = 0.042). Multivariate Cox regression confirmed that higher SI was protective (A: HR 0.53, B: 0.59, p ≤ 0.001), while MFI was associated with shorter survival (A: HR 1.31, B: 1.12, p < 0.01). The multivariate survival model trained on Hospital A's data demonstrated prognostic differentiation of groups in internal (n = 209, p ≤ 0.001) and external (Hospital B, n = 361, p = 0.044) validation, with SI feature importance (0.037) ranking below ECOG (0.082) and M-status (0.078), outperforming all other features including conventional L3-single-slice measurements. CONCLUSION: CT-based volumetric BCA provides prognostic biomarkers in lung cancer with varying significance by sex, disease stage and centre. SI was the strongest prognostic marker, outperforming conventional L3-based measurements, while fat-related markers showed varying associations. Our multivariate model suggests that BCA markers, particularly SI, may enhance risk stratification in lung cancer, pending centre-specific and sex-specific validation. Integration of these markers into clinical workflows could enable personalized care and targeted interventions for high-risk patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".