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Record W4413041567 · doi:10.4269/ajtmh.25-0200

Chagas and Vector-Borne Disease Exposures in an Indigenous Community in the Ecuadorian Amazon: A Retrospective Study

2025· article· en· W4413041567 on OpenAlexaff
Rojelio Mejía, Bin Zhan, Néstor L. Uzcátegui, Andrea Lopez, Philip J. Cooper, Natalia Romero-Sandoval

Bibliographic record

VenueAmerican Journal of Tropical Medicine and Hygiene · 2025
Typearticle
Languageen
FieldMedicine
TopicTrypanosoma species research and implications
Canadian institutionsInstitute of Infection and Immunity
Fundersnot available
KeywordsAmazon rainforestDengue feverChagas diseaseTrypanosoma cruziOdds ratioVector (molecular biology)LeishmaniaTransmission (telecommunications)IndigenousMedicineImmunologyVirologyVeterinary medicineEnvironmental healthBiologyInternal medicineParasite hostingEcology

Abstract

fetched live from OpenAlex

There are limited data on vector-borne diseases from the Ecuadorian Amazon, particularly among marginalized Indigenous populations. From a survey of Shuar communities in Ecuador, we measured IgG antibodies to Trypanosoma cruzi, dengue virus, and Leishmania spp. The prevalence of IgG antibodies was 7.4% for T. cruzi, 21.3% for dengue, and 96.8% for Leishmania spp. There was an increase in the risk of dengue infections with increasing age (per year; adjusted odds ratio [adj. OR]: 1.03, 95% CI: 1.01-1.05, P = 0.001) and among females (adj. OR: 2.17, 95% CI: 1.03-4.57, P = 0.041). There was an increase in T. cruzi anti-Tc24 IgG antibody levels with greater age (Spearman r = 0.553, P = 0.05). This study showed a high prevalence or exposure to Chagas disease, dengue, and Leishmania spp. There remains an unmet need for surveillance to monitor the transmission of Chagas and other vector-borne diseases and their associated morbidity in marginalized communities in the Ecuadorian Amazon.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.019
Threshold uncertainty score0.038

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.358
Teacher spread0.334 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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