Histone acetyltransferase p300/ <scp>CBP</scp> regulates reproductive diapause via the juvenile hormone pathway in the cabbage beetle, <i>Colaphellus bowringi</i>
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Bibliographic record
Abstract
Juvenile hormone (JH) serves as a pivotal endocrine regulator of reproductive diapause (also known as adult diapause) in insects, though the molecular mechanisms underlying JH signalling remain poorly characterised. In this study, we investigate the roles of the histone acetyltransferase p300/CBP in regulating reproductive diapause through JH signalling in the cabbage beetle Colaphellus bowringi. RNA interference-mediated knockdown of p300/CBP in reproductive females induced diapause-like phenotypes, including arrested ovarian maturation, suppressed vitellogenesis, increased lipid accumulation and upregulation of diapause-associated genes. These effects were accompanied by downregulation of key JH biosynthetic enzymes and signalling components. Although exogenous JH application decreased lipid accumulation, it failed to rescue ovarian development. Similar results were observed in diapause females following p300/CBP knockdown: JH analog treatment reduced lipid accumulations but did not restore ovarian development. Collectively, these findings demonstrate that p300/CBP regulates photoperiodic reproductive diapause by modulating both JH biosynthesis and signal transduction pathways in C. bowringi. Our results establish p300/CBP as a critical epigenetic mediator of JH-mediated reproductive diapause and provide new insights into the molecular mechanisms underlying environmental adaptation in insects.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it