TOR signalling mediates the collective movement of border cells in <i>Drosophila</i> oogenesis
Why this work is in the frame
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Bibliographic record
Abstract
Collective cell migration is seen in various biological processes spanning embryonic development, organogenesis, wound healing and, unfortunately, cancer metastasis. Here, we have examined the role of the evolutionarily conserved Target of Rapamycin signalling (TOR) in mediating collective cell movement employing the model of migrating border cells (BCs) in Drosophila oogenesis. Although TOR signalling is classically linked to cell growth, cell proliferation and metabolism, here we demonstrate that TOR complex 1 (TORC1) regulates efficient group cell movement of BCs. Employing live cell imaging, genetics, and tissue immunohistochemistry, we demonstrate that TOR functions through the transcription factor REPTOR to modulate Death-associated inhibitor of apoptosis 1 (Diap1) in mediating efficient movement of BCs. Coincidentally, rapamycin-treated myeloblast Kasumi-1 cells exhibit lower levels of transcript for the Diap1 homologue baculoviral IAP repeat-containing 2 (BIRC2), similar to what is observed in flies.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it