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Record W4413107121 · doi:10.7759/cureus.89793

Prosthetic Aortic Valve Endocarditis Caused by Burkholderia cepacia complex: A Case Report

2025· article· en· W4413107121 on OpenAlexaff
Khawar Tariq Mehmood, Amina Shahid

Bibliographic record

VenueCureus · 2025
Typearticle
Languageen
FieldMedicine
TopicInfective Endocarditis Diagnosis and Management
Canadian institutionsASTER
Fundersnot available
KeywordsMedicineEndocarditisBurkholderiaAortic valveBurkholderia cepacia complexProsthesisSurgeryAntibioticsMicrobiologyBacteria

Abstract

fetched live from OpenAlex

Prosthetic valve endocarditis (PVE) is a rare condition caused by infection of prosthetic heart valves (PHV) or repaired native valves. Onset from the time of implantation can be used to classify it into early and later categories. Gram-positive cocci are the predominant cause of early PVE (less than one year after implantation), though other less common organisms can also cause PVE. We report a case of early prosthetic valve endocarditis caused by gram-negative Burkholderia cepacia complex (BCC). This multidrug-resistant organism is an exceedingly rare cause of PVE. Only a handful of cases have been reported in medical literature. Its inherent resistance to the commonly used treatment modalities presents a unique challenge. Often, surgical intervention and removal of the prosthesis are required to ensure resolution. We present a case of prosthetic aortic valve endocarditis caused by Burkholderia cepacia (B. cepacia) that showed an excellent response to combination antibiotics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.003
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.002
Science and technology studies0.0030.002
Scholarly communication0.0020.002
Open science0.0010.002
Research integrity0.0070.004
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.314
Teacher spread0.293 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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