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Record W4413110351 · doi:10.1021/acs.chemrev.4c00996

Fluoropolymers in Medical Applications: Recent Progress and Development

2025· review· en· W4413110351 on OpenAlexafffund
Chadron M. Friesen, Jason Pulfer

Bibliographic record

VenueChemical Reviews · 2025
Typereview
Languageen
FieldMaterials Science
TopicElectrospun Nanofibers in Biomedical Applications
Canadian institutionsSimon Fraser UniversityTrinity Western UniversityWestern University
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsTetrafluoroethyleneChemistryMedical scienceMedical deviceNanotechnologyPolymerBiomedical engineeringOrganic chemistryMaterials scienceMedical educationEngineeringMedicine

Abstract

fetched live from OpenAlex

This article aims to present a comprehensive review of the medical applications of fluoropolymers from 2019 to October of 2024. Out of 532 articles, 291 were found to be relevant or imminently relevant to medical applications. The topics of use ranged from drug delivery, implants, sensors, and wound care, with 16 specific application categories noted. All fluorinated polymers were considered, from partially to fully fluorinated. A notable majority were comprised of poly(tetrafluoroethylene) (PTFE) or poly(vinylidene difluoride) (PVDF), leaving much room for additional research in these corresponding fields. The tension between the persistence of fluorinated materials in the environment versus longevity of the material in a medical device requires the need for education and understanding of the applications of fluoropolymers for human health. Fluoropolymers are vital to providing effective medical treatment for patients, especially in the format of long-term interventions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.978
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.376
Teacher spread0.342 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2025
Admission routes2
Has abstractyes

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