Normal meiosis in the fungus Sclerotinia sclerotiorum despite the irregular distribution of haploid chromosomes between two nuclei
Bibliographic record
Abstract
Sclerotinia sclerotiorum is a phytopathogenic soilborne fungus that damages diverse crops worldwide. It has recently been discovered that this fungus distributes its 16 chromosomes irregularly between two nuclei within each haploid ascospore. Here, we study the meiotic process by tracking phenotypic segregation and recombination events in the progeny of a strain resulting from the fusion of two morphologically distinct mutants. We show that, despite the unusual chromosomal distribution into two nuclei, chromosome segregation and genetic recombination occur normally in S. sclerotiorum, likely due to a tight coordination between the two complementing nuclei during meiosis. Consistently, an atypical ascospore development process deviating from the conventional model was observed. Furthermore, we show that our co-segregation analyses method can be used to identify causal mutations in uncharacterized mutants, uncovering a role for deubiquitination in fungal development and virulence. The fungus Sclerotinia sclerotiorum distributes its 16 chromosomes irregularly between two nuclei within single ascospore cells. Here, the authors show that chromosomal segregation and genetic recombination occur normally during meiosis in this fungus, despite the unusual chromosomal distribution.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".