A starch- and sucrose-reduced diet leads to a more favorable nutrient profile than low FODMAP in patients with irritable bowel syndrome. A randomized clinical trial
Bibliographic record
Abstract
A diet low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) and a starch- and sucrose-reduced diet (SSRD) both alleviate symptoms in IBS. Our hypothesis was that restrictive diets may preserve good nutritional supply. The aims of the study were to compare nutritional intake between SSRD and low FODMAP, and correlations between changes in nutrient intake, weight, and symptoms. This open, non-inferiority trial included patients with IBS according to Rome IV for a 4-week dietary intervention. Patients completed a 3-day food diary, study questionnaire, Rome IV questionnaire, IBS-severity scoring system (IBS-SSS), and visual analog scale for IBS (VAS-IBS) at baseline, after 4 weeks of either SSRD or low FODMAP, and at a 6-month follow-up. Daily intake of nutrients was calculated. In total, 155 patients (84 % women), 42 (32–55) years, weight 69.2 (63.0–82.9) kg, were included; 77 randomized to SSRD and 78 to low FODMAP diet. After 4 weeks, both SSRD and low FODMAP reduced symptoms, weight, and intake of calories, carbohydrates, sucrose, and monosaccharides, while vitamin D and B12 intake were increased. SSRD uniquely reduced added sugar, disaccharides, starch, and sodium chloride intake, while increasing protein, fat, vitamins, and minerals. In contrast, low FODMAP reduced intakes in fiber and several vitamins and minerals after 4 weeks and follow-up. The reductions of galacto-oligosaccharides and fructan were most pronounced in SSRD (p < 0.001). These findings highlight the SSRD's potential for broader health benefits and a more nutritionally balanced approach with higher nutrient density compared to the low FODMAP diet. Legend to Graphical Abstract : 155 patients with irritable bowel syndrome (IBS) were randomized to either a diet low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) or a starch- and sucrose-reduced diet (SSRD) with replacement of candies, soda and cereals with vegetables, fruit, dairy products, and egg for 4 weeks. Food diaries completed showed that SSRD increased the nutrient density at the same time as the energy intake was decreased. • A starch- and sucrose-reduced diet (SSRD) increased intake of vitamins and minerals. •A low FODMAP diet reduced intake of fiber, vitamins, and minerals. •The efficiency of symptom relief in IBS is equal between the diets. •The nutrient intake in SSRD is superior to low FODMAP.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".