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Record W4413149137 · doi:10.1016/j.cjco.2025.08.002

Reducing Socioeconomic Inequalities in Adult Cardiovascular Disease Risk by Targeting Unhealthy Movement Behaviours During Adolescence: A Protocol

2025· article· en· W4413149137 on OpenAlexafffund
Nicholas Grubic, Katerina Maximova, Arnaud Chioléro, Arjumand Siddiqi, Sarah Carsley, Brice Batomen, Kathleen Mullan Harris, Cristian Carmeli

Bibliographic record

VenueCJC Open · 2025
Typearticle
Languageen
FieldMedicine
TopicObesity, Physical Activity, Diet
Canadian institutionsHospital for Sick ChildrenMcGill UniversitySt. Michael's HospitalPublic Health OntarioUniversity of Toronto
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute on AgingNational Institute of Child Health and Human DevelopmentCanadian Institutes of Health ResearchMitacsUniversity of TorontoUniversity of North CarolinaSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungUniversity of North Carolina at Chapel HillNational Science Foundation
KeywordsSocioeconomic statusDiseaseInequalityProtocol (science)MedicineGerontologyEnvironmental healthPsychologyInternal medicinePathologyAlternative medicinePopulation

Abstract

fetched live from OpenAlex

Populations with lower socioeconomic position (SEP) are at increased risk of developing cardiovascular disease (CVD). Movement behaviours, including physical activity, sedentary behaviour, and sleep, contribute to socioeconomic gradients in CVD risk, as low-SEP populations are less likely to meet evidence-informed recommendations for these behaviours. Adolescence represents a sensitive period for establishing lifelong health behaviours, with CVD risk beginning to accumulate before adulthood. This study will model the potential effect of adolescent movement behaviour interventions on socioeconomic inequalities in adult CVD risk. We will conduct a population-based cohort study of adolescents from the Add Health study, recruited in 1994-1995 from the US and followed into adulthood. Unhealthy movement behaviours, including a low level of moderate-to-vigorous physical activity, a high level of recreational screen time, and short sleep duration, will be operationalized based on the 24-hour Movement Guidelines and measured twice during adolescence (ages 12-24 years). Parental educational attainment and family financial hardship will be used to capture SEP in adolescence. The outcome will be the 30-year risk of CVD, assessed in adulthood (ages 33-41 years) using a validated risk score that incorporates objectively measured biomarkers, demographic information, and self-reported health indicators. We will perform causal decompositions to quantify the change of socioeconomic inequalities in adult CVD risk under 2 interventional scenarios: (i) elimination (unhealthy movement behaviours are eliminated in the whole population of adolescents); and (ii) equalization (the distributions of unhealthy movement behaviours for low-SEP adolescents are equalized to those of high-SEP adolescents). This study will provide insights into how modifying adolescent movement behaviours may contribute to reducing socioeconomic inequalities in CVD risk.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.310
Teacher spread0.295 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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