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Record W4413269863 · doi:10.1038/s41598-025-16288-8

Declawing in Cat is associated with neuroplastic sensitization and long-term painful afflictions

2025· article· en· W4413269863 on OpenAlexafffund
Mathieu Lachance, Colombe Otis, Tristan Juette, Jérôme R. E. del Castillo, Aliénor Delsart, Maxim Moreau, Beatriz P. Monteiro, Aude Castel, Bertrand Lussier, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Éric Troncy

Bibliographic record

VenueScientific Reports · 2025
Typearticle
Languageen
FieldMedicine
TopicPain Mechanisms and Treatments
Canadian institutionsCegep de Saint HyacintheCentre Hospitalier de l’Université de MontréalUniversité de Montréal
FundersNatural Sciences and Engineering Research Council of CanadaElanco Animal HealthAbbott Animal HealthMitacsCanada Foundation for InnovationZoetis
KeywordsCATSMedicineSomatosensory systemChronic painOsteoarthritisAllodyniaNeuropathic painHyperalgesiaPhysical medicine and rehabilitationAnesthesiaNociceptionPhysical therapyPathologyInternal medicineReceptor

Abstract

fetched live from OpenAlex

Declawing of pet cats is widely believed to cause chronic pain and negatively impact animal welfare, leading to bans in many jurisdictions. However, little is known on how post-declaw pain develops and affects feline well-being. Existing data often fail to account for other sources of chronic pain, such as osteoarthritis (OA), which affects most aging cats. Here, the aim was to distinguish chronic post-declaw pain from OA-related pain. A secondary analysis of eight studies on feline OA was conducted, comparing somatosensory, biomechanical and functional assessments between healthy control cats, declawed OA (DOA) cats, and non-declawed OA (NDOA) cats. DOA cats exhibited significant somatosensory alterations (hyperalgesia and allodynia) and greater biomechanical (worse in heavier cats) and functional impairments, compared to NDOA cats. The alterations were not dependent on the number of declawed paws (two forelimbs vs. four paws). This alarming phenotype was associated with objective nervous conduction abnormalities indicative of worsened axonopathy in DOA cats. Our findings highlight the impact of chronic post-declaw pain and support the need to develop therapeutic strategies to alleviate chronic pain in DOA cats and highlights the pertinence of establishing a global ban of this elective procedure.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.256
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes2
Has abstractyes

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