Increases in cortisol production facilitate the transition to exogenous feeding by larval zebrafish
Bibliographic record
Abstract
The transition to exogenous feeding is a critical developmental period that is regulated by corticosteroids in mammals. However, mechanistic evidence linking corticosteroids with feeding transitions in non-mammalian vertebrates remains scarce. Here, we pharmacologically suppressed cortisol production during the period preceding exogenous feeding by larval zebrafish (Danio rerio) and determined how this influenced feeding rates and transcript levels of digestive enzymes. Water-borne metyrapone (an 11β-hydroxylase inhibitor) from 3-5 days post-fertilization (dpf) blocked the 2-fold rise in cortisol levels observed in control larvae during this period. While whole-animal growth and development were unaffected, cortisol synthesis suppression during this period resulted in lower transcript abundance of digestive enzymes and reduced feeding rates at 5 dpf. However, these differences dissipated following a two-day washout period. Together, our results indicate that cortisol influences feeding transitions in zebrafish, highlight the plasticity of these processes following perturbations, and suggest that this mechanism is conserved across vertebrates.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".