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Record W4413307243 · doi:10.1080/22221751.2025.2547724

Structural basis for broad neutralization of rabies virus by an antibody cocktail SYN023

2025· article· en· W4413307243 on OpenAlexaff
Lei Cao, Jiagui Qu, Chun Zhang, Ruihong Chen, Jinyue Wang, Christine Fehlner‐Gardiner, Michael Niezgoda, Panayampalli S. Satheshkumar, Xiangxi Wang, Eric Tsao

Bibliographic record

VenueEmerging Microbes & Infections · 2025
Typearticle
Languageen
FieldImmunology and Microbiology
TopicRabies epidemiology and control
Canadian institutionsLab_Bell (Canada)Canadian Food Inspection Agency
FundersNational Science Fund for Distinguished Young ScholarsNational Key Research and Development Program of ChinaBeijing Municipal Natural Science FoundationYouth Innovation Promotion AssociationMinistry of Science and Technology of the People's Republic of ChinaNational Natural Science Foundation of China
KeywordsVirologyNeutralizationRabies virusRabiesAntibodyVirusLyssavirusBiologyRhabdoviridaeImmunology

Abstract

fetched live from OpenAlex

Dear Editor,Rabies is a severe zoonotic disease with nearly 100% mortality once symptoms appear1,2. Prevention relies on prompt post-exposure prophylaxis (PEP), which includes vaccination and the a...

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.257
Threshold uncertainty score0.801

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.302
Teacher spread0.292 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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