The Impact of Young and/or Exercised Blood Plasma Transfusions in Individuals With Neurodegenerative Conditions: Protocol for a Scoping Review
Bibliographic record
Abstract
BACKGROUND: The prevalence of neurodegenerative conditions is expected to continue to rise, with current treatments largely focused on the management of symptoms and not disease progression. Exercise is a therapy that has significant favorable effects on several of the modifiable risk factors that influence the development/progression of some neurodegenerative conditions. However, there are significant barriers to exercise for this population, warranting consideration of alternative or adjunct therapies. Blood plasma transfusion is an emerging nonpharmaceutical/nonexercise therapy that may have positive benefits on people and animal models with neurodegenerative conditions. OBJECTIVE: The aim of this study was to investigate and synthesize the literature on the impacts of young or exercised blood plasma transfusions in people and animal models with neurodegenerative conditions. METHODS: We will include studies that have explored the impacts of young or exercised blood plasma transfusions in adults or animal models with neurodegenerative conditions. PubMed Central, MEDLINE, Cochrane Database of Systematic Reviews, Scopus, ProQuest, SPORTDiscus, PROSPERO, and multiple unpublished sources, including book chapters, conference papers, and theses, will be searched to include literature from January 2004 to May 2024, written in English. Studies will be screened by 2 independent reviewers; a third reviewer will be used to resolve any conflicts. Data will be extracted into a modified charting tool and will be presented in a graphical or tabular format combined with the appropriate narration. RESULTS: As of June 2024, the literature search has been completed. After searching listed databases, 3646 citations and 13 gray literature studies were identified, of which 1432 duplicates were removed. CONCLUSIONS: To the best of our knowledge, this study will be the first study with the aim of investigating the literature on the impacts of young or exercised blood plasma transfusions in individuals with neurodegenerative conditions. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/65935.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.089 | 0.098 |
| Meta-epidemiology (narrow) | 0.007 | 0.006 |
| Meta-epidemiology (broad) | 0.017 | 0.020 |
| Bibliometrics | 0.016 | 0.014 |
| Science and technology studies | 0.006 | 0.005 |
| Scholarly communication | 0.008 | 0.010 |
| Open science | 0.006 | 0.008 |
| Research integrity | 0.011 | 0.007 |
| Insufficient payload (model declined to judge) | 0.069 | 0.011 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".