Maintenance Infusion Rate of Oxytocin After Initial 1-IU Bolus for Elective Cesarean Delivery: A Dose-Finding Study
Bibliographic record
Abstract
( Can J Anesth . 2024;71:1363–1371. DOI: 10.1007/s12630-024-02828-9) Postpartum hemorrhage (PPH) is a major cause of maternal death, and oxytocin is recommended after placenta delivery to reduce PPH risk by up to 40%. It is given as an intravenous bolus followed by a maintenance infusion (OMI) to sustain uterine tone. Current guidelines suggest an initial 1 IU bolus, followed by an OMI of 2.5 to 7.5 IU/h. Previous studies in elective cesarean deliveries (CDs) found the minimum effective dose (ED90) without an initial bolus to be 16.2 to 17.4 IU/h. Given the variability in dosing strategies and limited evidence on oxytocin regimens after a bolus, this study aimed to determine the ED90 of OMI after an initial bolus, hypothesizing that the required dose would be lower.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".