Maintenance Infusion Rate of Oxytocin After Initial 1-IU Bolus for Elective Cesarean Delivery: A Dose-Finding Study
Bibliographic record
Abstract
(Can J Anesth. 2024;71:1363–1371. DOI: 10.1007/s12630-024-02828-9) Postpartum hemorrhage (PPH) is a major cause of maternal death, and oxytocin is recommended after placenta delivery to reduce PPH risk by up to 40%. It is given as an intravenous bolus followed by a maintenance infusion (OMI) to sustain uterine tone. Current guidelines suggest an initial 1 IU bolus, followed by an OMI of 2.5 to 7.5 IU/h. Previous studies in elective cesarean deliveries (CDs) found the minimum effective dose (ED90) without an initial bolus to be 16.2 to 17.4 IU/h. Given the variability in dosing strategies and limited evidence on oxytocin regimens after a bolus, this study aimed to determine the ED90 of OMI after an initial bolus, hypothesizing that the required dose would be lower.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.009 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".