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Record W4413346206 · doi:10.1136/emermed-2025-215149

Early prophylactic antibiotics following endotracheal intubation for traumatic brain injury may reduce respiratory complications

2025· article· en· W4413346206 on OpenAlexaff
Luke Dearden, Melissa Drake, Daniel Horner

Bibliographic record

VenueEmergency Medicine Journal · 2025
Typearticle
Languageen
FieldMedicine
TopicNosocomial Infections in ICU
Canadian institutionsInstitute of Infection and Immunity
Fundersnot available
KeywordsMedicineTraumatic brain injuryIntubationPneumoniaAntibioticsEndotracheal intubationIntensive care medicineVentilator-associated pneumoniaAnesthesiaIntensive care unitInternal medicine

Abstract

fetched live from OpenAlex

A rapid literature review was carried out to examine the evidence supporting early prophylactic antibiotics use following endotracheal intubation in patients traumatic brain injury (TBI), to reduce the risk of subsequent ventilator-associated pneumonia. Four papers were identified as suitable for inclusion using the reported search strategy. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of the best papers are tabulated. Current evidence suggests that early administration of prophylactic antibiotics to patients with severe TBI requiring endotracheal intubation reduces the risk of subsequent pneumonia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.502
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.090
GPT teacher head0.437
Teacher spread0.347 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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