MétaCan
Menu
Back to cohort
Record W4413355634 · doi:10.1093/ofid/ofaf463

Assessment of Cross-Reactive Neutralizing Antibodies Induction Against H5N1 Clade 2.3.4.4b by Prior Seasonal Influenza Immunization in Retail Workers

2025· article· en· W4413355634 on OpenAlexafffund
Andrea Arroyave, Henintsoa Rabezanahary, Aude Wantchecon, Vonintsoa Lalaina Rahajamanana, Ahmed Sahli, Mathieu Thériault, Denis Boudreau, Caroline Gilbert, Sylvie Trottier, Mariana Baz

Bibliographic record

VenueOpen Forum Infectious Diseases · 2025
Typearticle
Languageen
FieldMedicine
TopicInfluenza Virus Research Studies
Canadian institutionsUniversité LavalCentre hospitalier universitaire de Québec
FundersFonds de recherche du QuébecCanada First Research Excellence FundCanada Research ChairsPublic Health Agency of CanadaUniversité Laval
KeywordsInfluenza A virus subtype H5N1ImmunizationAntibodyVirologyCladeMedicineCross-reactivitySeasonal influenzaImmunityImmune systemHighly pathogenicImmunologyCoronavirus disease 2019 (COVID-19)BiologyCross reactionsVirusGeneInternal medicinePhylogenetics

Abstract

fetched live from OpenAlex

This study evaluated whether immunity from seasonal influenza induces cross-reactive antibodies against recent avian and bovine H5N1 strains in serum from retail workers. Despite strong neutralizing activity against seasonal strains, no cross-reactivity against H5N1 was detected, emphasizing the need to assess broader immune responses and targeted vaccines for H5N1 viruses.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.032
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041
GPT teacher head0.424
Teacher spread0.383 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes2
Has abstractyes

Explore more

Same venueOpen Forum Infectious DiseasesSame topicInfluenza Virus Research StudiesFrench-language works237,207