Comparative Analysis of Foundational and Traditional Deep Learning Models for Hyperpolarized Gas MRI Lung Segmentation: Robust Performance in Data-Constrained Scenarios
Bibliographic record
Abstract
This study investigates the comparative performance of foundational models versus traditional deep learning architectures for hyperpolarized gas MRI segmentation under both full data and limited data conditions. Chronic obstructive pulmonary disease (COPD) remains a leading global health concern, and advanced imaging techniques are crucial for its diagnosis and management. Hyperpolarized gas MRI, utilizing helium-3 (³He) and xenon-129 (¹²⁹Xe), offers a non-invasive way to assess lung function. Foundational models, pre-trained on diverse and expansive datasets, theoretically offer advantages in scenarios with limited task-specific data compared to traditional architectures that rely heavily on large training datasets. This study evaluates this hypothesis by comparing foundational models, Segment Anything Model (SAM) and Segment Anything in Medical Images (MedSAM) against traditional deep learning architectures (UNet with VGG19 backbone, Feature Pyramid Network with MIT-B5 backbone, and DeepLabV3 with ResNet152 back-bone) using both full dataset (1640 2D MRI slices from 205 participants) and limited data scenarios (25% of the full dataset). Our experimental design included fine-tuning all models on the complete dataset and subsequently on the reduced dataset to assess performance degradation and resilience to data scarcity. Results demonstrate that while traditional models achieve competitive performance with full data availability, foundational models exhibit superior robustness and maintain performance in limited data scenarios. The fine-tuned MedSAM model showed the least performance degradation when transitioning from full to limited data conditions, achieving superior Dice Similarity Coefficient (DSC) and Hausdorff Distance (HD95) metrics compared to traditional architectures. This work highlights the critical advantage of foundational models in medical imaging applications where data collection is challenging, expensive, or ethically constrained, demonstrating their potential to democratize advanced medical imaging analysis in resource-limited settings.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.007 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".