Eruptive acral syringomas: A case report and review of literature
Bibliographic record
Abstract
We present a case of a 43-year-old woman with Vogt-Koyanagi-Harada syndrome, on adalimumab, methotrexate, and risedronate, who developed pruritic, skin-colored papules on the dorsal hands. A biopsy revealed features consistent with syringomas. Syringomas are benign eccrine duct tumors that typically appear as small, shiny papules, most often in the periorbital area but can also present in acral regions. Only 14 cases of exclusive acral syringomas have been reported. Eruptive variants may resemble conditions such as lichen nitidus or warts, making dermoscopy and histopathology crucial for diagnosis. Dermoscopically, syringomas may show fine reticulate brown lines and homogenous pigmentation. Histologically, they show small ductal structures and epithelial cords in the dermis. Their exact pathogenesis remains unclear, possibly involving hormonal or inflammatory triggers. Treatment is challenging due to their dermal depth and recurrence risk, with lasers and retinoids among the options. This case highlights the diagnostic complexity of acral eruptive syringomas.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.007 | 0.006 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".