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Record W4413836369 · doi:10.1111/sms.70130

Six Weeks of Low‐Volume Sprint Interval Training Improves Peak Oxygen Uptake Compared to a Non‐Exercise Control: A Randomized Controlled Trial

2025· article· en· W4413836369 on OpenAlexafffund
John R. M. Renwick, Jeff Crukley, Masa Kudsi, E Binet, Jack Bone, Noah J. Mulkewich, Fiona J. Babir, Brendon J. Gurd, Martin J. Gibala

Bibliographic record

VenueScandinavian Journal of Medicine and Science in Sports · 2025
Typearticle
Languageen
FieldMedicine
TopicCardiovascular and exercise physiology
Canadian institutionsQueen's UniversityMcMaster University
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsSprintInterval trainingVO2 maxMedicineHigh-intensity interval trainingConfidence intervalRandomized controlled trialPhysical therapyInternal medicineHeart rate

Abstract

fetched live from OpenAlex

ABSTRACT Low‐volume sprint interval training (LVSIT) increases peak oxygen uptake (VO2peak) when performed three times a week for 6 weeks. Methodological and statistical concerns, however, constrain the veracity of prior findings. We therefore reassessed the VO2peak response to LVSIT using a randomized controlled trial design to mitigate bias and augment reporting quality. A generative model of VO2peak was constructed as a function of group, baseline VO2peak, age, sex, height, and change in body mass. Simulation experiments using previous data estimated that n = 15/group would achieve 80% power to detect a difference of 1 metabolic equivalent (MET) with a credible interval (CrI) of ≤ 1‐MET. Insufficiently active young adults (22 ± 3 years, body mass index: 24 ± 4 kg m−2, baseline VO2peak: 33 ± 7 mL kg−1 min−1) were randomized to perform 6 weeks of thrice weekly LVSIT (n = 17) or no exercise (CTL; n = 20). The LVSIT protocol involved 3 × 20‐s “all out” sprints over a 10‐min session of low‐intensity cycling. Bayesian generative multivariate modeling revealed that LVSIT increased absolute [+325 mL min−1 (101–605)] and relative VO2peak [+5.6 mL kg−1 min−1 (2.2–8.1)] versus CTL. All but one LVSIT participant (94%) were deemed a responder (i.e., mean estimate ± 95% CrI for relative VO2peak > 0). In contrast, four CTL participants (20%) met this criterion. LVSIT also improved time to exhaustion by +133 s (101–160) versus CTL. We unequivocally demonstrate that 6 weeks of thrice weekly LVSIT increased VO2peak in insufficiently active young adults compared to no exercise. By incorporating a robust design that included preregistration, concealed allocation assignment, statistical best practices, and applied Bayesian methods, and open data‐sharing, this study addresses prior methodological critiques of similar previous work.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0030.003
Insufficient payload (model declined to judge)0.0070.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.290
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes2
Has abstractyes

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