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Record W4413846771 · doi:10.1016/j.ijcha.2025.101783

Evaluating artificial intelligence-enabled medical tests in cardiology: Best practice

2025· review· en· W4413846771 on OpenAlexaff
Jonas L. Isaksen, Malene Nørregaard, Martin Manninger, Dobromir Dobrev, Thomas Jespersen, B J M Hermans, Jordi Heijman, Gernot Plank, Thomas Pock, Vajira Thambawita, Michael A. Riegler, Jørgen K. Kanters, Dominik Linz

Bibliographic record

VenueIJC Heart & Vasculature · 2025
Typereview
Languageen
FieldMedicine
TopicCardiac Imaging and Diagnostics
Canadian institutionsUniversité de MontréalMontreal Heart Institute
FundersNovo Nordisk FondenHartstichtingAustrian Science FundZonMwVillum FondenNovo NordiskDanish Cardiovascular AcademyEuropean Federation of Pharmaceutical Industries and AssociationsHORIZON EUROPE Framework ProgrammeNederlandse Organisatie voor Wetenschappelijk OnderzoekNational Institutes of HealthHjerteforeningenEuropean CommissionDeutsche ForschungsgemeinschaftDanish Data Science Academy
KeywordsMedicineMedical physicsCardiologyInternal medicine

Abstract

fetched live from OpenAlex

Machine learning methods are increasingly used in cardiovascular research. In order to highlight opportunities and challenges of the evaluation of studies applying machine learning, we use examples from cardiac electrophysiology, a field characterized by large and often imbalanced amounts of data. We provide recommendations and guidance on evaluating and presenting supervised machine learning studies. We recommend proper cohort selection, keeping training and testing data strictly separate, and comparing results to a reference model without machine learning as basic principles to ensure the quality of studies using machine learning methods. We furthermore recommend specific metrics and plots when reporting on machine learning including on models for multi-channel time series or images. This Best Practice paper represents a possible blueprint to help evaluate machine learning-based medical tests in cardiac electrophysiology and beyond.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.056
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Research integrity
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.975
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.056
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0040.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.098
GPT teacher head0.478
Teacher spread0.380 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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