Gradient Myopic Defocus Causes Chick Scleral Tissue Reinforcement and Structural Scleral Remodeling
Why this work is in the frame
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Bibliographic record
Abstract
PURPOSE: To determine histological effects of myopia progression control (MPC) lens-induced refractive changes on scleral remodeling in chicks. METHODS: 24 Ross-Ross chicks were raised for 14 days. 6 chicks wore conventional -10D lenses for 7 days, followed by no lenses for 7 days. 6 chicks wore conventional -10D lenses for the full 14 days. 6 chicks wore conventional -10D lenses for 7 days, followed by +10D lenses for 7 days. 6 chicks wore conventional -10D lenses for 7 days, followed by MPC lenses for 7 days. MPC lenses had a central power of -10D and a gradient power rise at pupil edge (+2.75D). Chicks were euthanized after 14 days and eyes were processed for histopathological evaluation. Whole mount H&E-stained tissue sections were analyzed using bright field microscopy. RESULTS: > 0.05). CONCLUSION: It is possible to induce appositional growth in hyaline cartilage in the chick sclera. In our study, this has only been achieved by using MPC lenses to reverse previously induced experimental myopia with conventional minus lenses. Our findings suggest that a gradient decrease in peripheral lens power and the resulting differential defocus could trigger of scleral reinforcement through of cartilage growth stimulation in the chick sclera.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it