Anomalous hydration of glycolipid ohmline revealed by surface-specific vibrational spectroscopy
Bibliographic record
Abstract
Glycolipids are key structural and functional components of biological membranes, yet their interfacial hydration behavior remains poorly understood. Here, we use vibrational heterodyne-detected sum-frequency generation (HD-SFG) spectroscopy to probe the molecular structure of the air-water interface formed by monolayers of ohmline, a glycolipid bearing a lactose headgroup and carrying no formal charge. Upon electrolyte addition, we observe a striking reorientation of interfacial water and a reversal of the HD-SFG signal, indicative of apparent surface charging by an otherwise neutral headgroup. This charge-like behavior stems from ion-specific interactions: cations exhibit strong affinity for the glycolipid interface, while anion effects are comparatively weak. Quantitative analysis reveals that approximately one cation is trapped per ∼16 ohmline molecules. These results uncover an unconventional hydration mechanism for glycolipids, distinguishing them from classical phospholipids and shedding light on salt-modulated self-assembly processes such as the reversible formation of lipid nanotubes (LNTs). Our findings establish a framework for understanding ion-mediated phenomena in glycolipid-rich interfacial systems, with implications for membrane biophysics and soft materials design.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".