Unravelling symptom-specific polygenic effects on maternal mental health during the perinatal period and postpartum
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Polygenic score analysis of maternal mental health symptoms; a substantive genetics question.
The study investigates genetic associations with maternal mental-health symptoms.
Genetic epidemiology of maternal mental health symptoms; clinical/psychiatric genetics object, not metaresearch.
Abstract
BACKGROUND: While genetic factors are important influences on maternal mental health, few studies have used symptom-level analyses to examine how genetic liability is related to the experience of specific mental health problems in mothers. A symptom-level approach can account for disorder heterogeneity and delineate key associations between genetic liabilities and mental health. METHODS: Three waves of data (30 weeks of gestation, 6 and 18 months postpartum) from the Norwegian Mother, Father and Child Cohort Study (MoBa) were used to assess item-level associations between genetic liabilities to depression, anxiety, neuroticism and positive affect, and maternal mental health phenotypes (i.e., symptoms of anxiety, depression, positive and negative affect) using a network analysis approach. Sample sizes ranged from 46,537 to 59,308 mothers. RESULTS: PGSs exhibited both phenotype-specific associations (e.g., depression PGS linked with hopelessness, anxiety PGS linked with worry) and cross-phenotype (e.g., depression PGS linked with nervousness, positive affect PGS inversely related to anxiety and depressive symptoms) relationships, with partial correlations ranging between r = -0.025 and r = 0.024. Some PGS-phenotype associations were consistent (e.g., depression PGS linked with feeling like screaming or banging on something across all waves) and others inconsistent (e.g., anxiety PGS linked with nervousness only at 6 months postpartum) across the perinatal and postpartum periods. CONCLUSIONS: Our findings highlight symptom-level associations between PGSs and maternal mental health, which may be obscured when global measures of mental health (e.g., overall scores) are used. Identifying symptom-specific PGS associations could advance current understanding of aetiological influences on maternal mental health.
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The record
- Venue
- Journal of Affective Disorders
- Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Field
- Medicine
- Canadian institutions
- —
- Funders
- Norwegian Institute of Public HealthHelse Sør-Øst RHFUtdannings- og forskningsdepartementetNorges ForskningsrådNovo Nordisk FondenUniversitetet i OsloUniversitetet i BergenNordForskEnergy Council of CanadaRéseau de cancérologie RossyHelse VestHelse- og OmsorgsdepartementetTrond Mohn stiftelseStiftelsen Kristian Gerhard Jebsen
- Keywords
- Perinatal periodPostpartum periodMental healthPeriod (music)PsychiatryPregnancyMedicinePsychologyBiologyGenetics
- Has abstract in OpenAlex
- yes