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Record W4414070257 · doi:10.1051/medsci/2025099

Modèles cellulaires de l’inflammation dans le segment postérieur de l’œil

2025· review· fr· W4414070257 on OpenAlexafffund
Gabrielle Raîche-Marcoux, Sylvain L. Guérin, Élodie Boisselier

Bibliographic record

Venuemédecine/sciences · 2025
Typereview
Languagefr
FieldMedicine
TopicGlaucoma and retinal disorders
Canadian institutionsUniversité LavalCentre hospitalier de l'Université Laval
FundersNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health Research
KeywordsInflammationCell typeCellDiabetic retinopathyRetinaCell culture

Abstract

fetched live from OpenAlex

Le glaucome, la dégénérescence maculaire liée à l’âge et la rétinopathie diabétique sont des maladies oculaires complexes et partiellement inflammatoires. Plusieurs modèles cellulaires sont développés pour étudier les mécanismes de l’inflammation retrouvés dans le segment postérieur de l’œil. Ces modèles, constitués de cellules d’origines diverses (humaines ou animales), issues de tissus variés (rétine, choroïde, peau, cordon ombilical) et appartenant à différents types cellulaires (épithéliaux, endothéliaux, vasculaires, neuronaux), font appel à de multiples techniques de culture afin de permettre l’analyse des réponses inflammatoires spécifiques. Diverses approches expérimentales sont utilisées pour induire l’inflammation dans ces modèles cellulaires et pour identifier les mécanismes moléculaires sous-jacents. La revue souligne la diversité des modèles cellulaires employés dans l’étude de l’inflammation oculaire postérieure, en mettant en avant l’utilisation de cultures de cellules primaires, de lignées cellulaires établies ainsi que les différentes approches de co-culture, dans le but d’approfondir la compréhension de ces maladies oculaires qui affectent des millions de personnes à travers le monde.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.818
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.301
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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