Sex-specific behavioral impairments and neuronal alterations in Wistar rats following repeated sevoflurane exposure during developmental stages
Why this work is in the frame
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Bibliographic record
Abstract
OBJECTIVES: This study aimed to investigate the effects of repeated exposure to sevoflurane as an anesthetic agent during various developmental stages, namely neonatal, preadolescent, and adult, on behavioral, synaptic, and neuronal plasticity in male and female Wistar rats. METHODS: Rats were exposed to sevoflurane during three developmental stages: neonatal (PN7), pre-adolescence (PN28), and adulthood (PN90). Behavioral performance was evaluated with the Morris Water Maze. Electrophysiological analyses measured population spike (PS) amplitude, slope, and long-term potentiation (LTP) to assess synaptic plasticity. Short-term plasticity was additionally studied using paired-pulse facilitation tests. RESULTS: Repeated neonatal exposure to sevoflurane caused significant impairments in spatial learning and memory, whereas exposures during pre-adolescence and adulthood had minimal effects. Electrophysiological data revealed a reduction in PS amplitude and slope, as well as impaired LTP, particularly in neonatal and pre-adolescent groups, with more severe deficits observed in males. Paired-pulse facilitation indicated greater short-term plasticity deficits in males at shorter intervals. DISCUSSION: The findings of this study highlight the increased vulnerability of the developing brain, particularly during the neonatal period, to the adverse effects of repeated exposure to sevoflurane, resulting in long-lasting impairments in synaptic function and behavior. The results emphasize the importance of caution when administering sevoflurane to young children and suggest that early-life exposure may have lasting effects on cognitive and synaptic health.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it