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Record W4414109037 · doi:10.1200/cci-25-00042

Enhancing Readability of Lay Abstracts and Summaries for Urologic Oncology Literature Using Generative Artificial Intelligence: BRIDGE-AI 6 Randomized Controlled Trial

2025· article· en· W4414109037 on OpenAlex
Conner Ganjavi, Ethan Layne, Francesco Cei, Karanvir Gill, Vasileios Magoulianitis, Andre Luis Abreu, Mitchell G. Goldenberg, Mihir Desai, Inderbir S. Gill, Giovanni Cacciamani

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueJCO Clinical Cancer Informatics · 2025
Typearticle
Languageen
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsArtificial Intelligence in Medicine (Canada)
Fundersnot available
KeywordsReadabilityRandomized controlled trialComprehensionQuality (philosophy)MEDLINEClinical trial

Abstract

fetched live from OpenAlex

PURPOSE To evaluate a generative artificial intelligence (GAI) framework for creating readable lay abstracts and summaries (LASs) of urologic oncology research, while maintaining accuracy, completeness, and clarity, for the purpose of assessing their comprehension and perception among patients and caregivers. METHODS Forty original abstracts (OAs) on prostate, bladder, kidney, and testis cancers from leading journals were selected. LASs were generated using a free GAI tool, with three versions per abstract for consistency. Readability was compared with OAs using validated metrics. Two independent reviewers assessed accuracy, completeness, and clarity and identified AI hallucinations. A pilot study was conducted with 277 patients and caregivers randomly assigned to receive either OAs or LASs and complete comprehension and perception assessments. RESULTS Mean GAI-generated LAS generation time was <10 seconds. Across 600 sections generated, readability and quality metrics were consistent ( P > .05). Quality scores ranged from 85% to 100%, with hallucinations in 1% of sections. The best test showed significantly better readability (68.9 v 25.3; P < .001), grade level, and text metrics compared with the OA. Methods sections had slightly lower accuracy (85% v 100%; P = .03) and trifecta achievement (82.5% v 100%; P = .01), but other sections retained high quality (≥92.5%; P > .05). GAI-generated LAS recipients scored significantly better in comprehension and most perception-based questions ( P < .001) with LAS being the only consistently significant predictor ( P < .001). CONCLUSION GAI-generated LASs for urologic oncology research are highly readable and generally preserve the quality of the OAs. Patients and caregivers demonstrated improved comprehension and more favorable perceptions of LASs compared with OAs. Human oversight remains essential to ensure the accurate, complete, and clear representations of the original research.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.017
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.452
Threshold uncertainty score0.991

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0060.017
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.253
GPT teacher head0.550
Teacher spread0.297 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it