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Record W4414114803 · doi:10.1016/j.jgeb.2025.100569

Decoding the cannabis tissue culture puzzle: Machine learning analysis of cannabis in vitro morpho-physiological disorders expands the potential for precision micropropagation

2025· article· en· W4414114803 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueJournal of Genetic Engineering and Biotechnology · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPlant tissue culture and regeneration
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsMicropropagationCannabisCannabis sativaPlant tissue cultureTissue cultureSynthetic cannabinoids

Abstract

fetched live from OpenAlex

Cannabis sativa L. (cannabis) has recently re-emerged as an economically important crop, fueling research focused on enhancing production practices to meet market demands. The developing cannabis industry can be improved by overcoming certain production hurdles using micropropagation to maintain and multiply pathogen-free plants in confined spaces at high volumes. However, developing efficient micropropagation systems for cannabis have been hampered by the prevalence of various morpho-physiological disorders, resulting in low multiplication rates, culture decline, and overall low efficiency rates. While progress in cannabis micropropagation has been made, nutrient imbalances and various disorders are still common. Successful micropropagation is species specific and dependent on a variety of interconnected factors related to abiotic conditions and nutrient availability, which represent challenges in the refinement and execution of effective methods. Micropropagation media represent the exclusive sources of macro- and micro-nutrients for cultured plant tissues, inadequacies of which can result in the emergence of morpho-physiological symptoms. This work represents the first in-depth analysis of multiple morpho-physiological disorders in micropropagated cannabis arising from media nutrient content. Additionally, we present machine learning as an effective tool for assessing nutrient-associated symptoms in cultured cannabis and identifying which components are responsible. Results will help with troubleshooting cannabis micropropagation systems to prevent or correct undesirable outcomes, while introducing new methods to assess in vitro cannabis disorders.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.059
Threshold uncertainty score0.205

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.003
GPT teacher head0.219
Teacher spread0.216 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it