Heart DHA turnover is faster in female compared to male ALA- and EPA-fed mice
Bibliographic record
Abstract
C-n-3 PUFA values modeled by one-phase exponential decay. Compared to males, females exhibited slower turnover of ALA (48%-61% slower) and DPAn-3 (26%-73% slower) from dietary ALA or EPA in the heart, PRAT, and RBCs, resulting from longer half-lives and/or lower DPAn-3 concentrations. Conversely, females showed 26%-28% faster heart DHA turnover from dietary ALA or EPA, despite similar half-lives between sexes. Notably, sex-specific differences in DHA turnover were present only in the heart, whereas DPAn-3 turnover varied across multiple tissues, suggesting a heart-specific mechanism that enhances DHA metabolism in females under low DHA intake. Further research is needed to investigate the physiological significance of these metabolic differences and their potential health implications.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".