MétaCan
Menu
← Back to cohort
Record W4414258301 · doi:10.1101/2025.09.11.675513

Cerebellar growth is associated with domain-specific cerebral maturation and socio-linguistic behavioral outcomes

2025· preprint· en· W4414258301 on OpenAlexafffund
Aikaterina Manoli, Neville Magielse, Felix Hoffstaedter, Thanos Tsigaras, Augustijn de Boer, Lorenz Ahle, Ceyda YALÇIN, Milin Kim, Torgeir Moberget, Thomas Wolfers, Casey Paquola, Charlotte Grosse Wiesmann, André F. Marquand, Jörn Diedrichsen, Sofie L. Valk

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldNeuroscience
TopicVestibular and auditory disorders
Canadian institutionsWestern University
FundersRaynor Cerebellum ProjectHector StiftungCanada First Research Excellence FundMax-Planck-GesellschaftJacobs FoundationUniversity of MinnesotaMcGill UniversityStudienstiftung des Deutschen Volkes
KeywordsCerebellumCognitionBrain developmentNormativeCerebellar cortex

Abstract

fetched live from OpenAlex

Abstract The cerebellum’s involvement in cognitive functions is increasingly recognized, yet its developmental contribution to cognition remains poorly understood. The cerebellum undergoes rapid development in early life, paralleling major cognitive and behavioral changes. Although clinical studies have linked early cerebellar disruptions to profound developmental deficits, it remains largely unclear how typical cerebellar maturation supports the development of cognitive functions and how it interacts with broader brain development. Here, we apply a normative modeling framework to map cerebellar volumetric growth from infancy to young adulthood ( N = 751; ages 1-21 years). Using lobular and functional cerebellar parcellations, we comprehensively characterize typical cerebellar development and examine how it aligns with cerebral development and behavioral outcomes. Across parcellations, posterior higher association areas consistently show steeper growth trajectories than anterior sensorimotor areas. Cerebellar and cerebral areas with similar functional roles demonstrate coordinated maturation, and volumetric growth in the posterior cerebellum relates to individual differences in socio-linguistic behaviors. These findings establish a comprehensive reference for typical cerebellar development, highlight cerebellar co-maturation with the cerebral cortex, and underscore the cerebellum’s role in supporting emerging higher cognitive functions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.014
Threshold uncertainty score0.028

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.235
Teacher spread0.217 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

Explore more

Same venuebioRxiv (Cold Spring Harbor Laboratory)→Same topicVestibular and auditory disorders→French-language works237,207→