Feasibility of Subcutaneous Immunoglobulin Therapy as the Maintenance Therapy in Patients with Autoimmune Neuromuscular Disease: A Prospective Study
Bibliographic record
Abstract
Long-term immunoglobulin therapy is crucial for several neuromuscular disorders (NMD). Recently, subcutaneous immunoglobulin (SCIg) has become an alternate to intravenous immunoglobulin (IVIg) for maintenance therapy to address limitations. This prospective study assessed the feasibility of SCIg as maintenance therapy for various NMDs after transitioning from IVIg. Overall, the mean monthly immunoglobulin dose remained stable or reduced after transition while maintaining efficacy. Participants reported significantly fewer side effects (29.2 % vs. 66.7%) with SCIg. Compliance with self-infusion and dosing regimen with SCIg was high, with no product wastage. The study shows SCIg therapy has distinct advantages over IVIg and should be considered for NMD patients requiring maintenance therapy.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.005 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".