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Record W4414402546 · doi:10.1073/pnas.2503399122

VOC injection into a house reveals large surface reservoir sizes in an indoor environment

2025· article· en· W4414402546 on OpenAlexafffund
Jie Yu, Pascale S. J. Lakey, Jenna C. Ditto, Han N. Huynh, Michael F. Link, Dustin Poppendieck, Stephen M. Zimmerman, Xing Wang, Delphine K. Farmer, Marina E. Vance, Jonathan P. D. Abbatt, Manabu Shiraiwa

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2025
Typearticle
Languageen
FieldEnvironmental Science
TopicIndoor Air Quality and Microbial Exposure
Canadian institutionsUniversity of Toronto
FundersNatural Sciences and Engineering Research Council of CanadaAlfred P. Sloan Foundation
KeywordsContaminationVolatile organic compoundPorosityPartition (number theory)Volatility (finance)Organic chemicalsPartition coefficientVolume (thermodynamics)

Abstract

fetched live from OpenAlex

The total partitioning capacity of indoor surface reservoirs determines the mechanism by which humans receive nondietary exposure to organic contaminants, via inhalation, dermal uptake, and dust ingestion. And yet, this capacity is largely unknown. Surface organic films are ubiquitously present but have very low partitioning volume being only 10’s of nanometer thick, whereas other surface reservoirs such as building materials and furnishings can be permeable or porous with large surface areas at the molecular level. Here, we assess the total partitioning capacity of volatile organic compounds (VOCs) in an indoor environment from the measured kinetics of VOC surface uptake after injection of compounds with variable volatility into a well-characterized, unoccupied test house. We show that the size of the indoor surface reservoirs is very large with an octanol-equivalent average thickness on the order of micrometers, indicating that permeable/porous materials such as painted surfaces and wood are likely the major surface reservoirs in the house rather than organic surface films. Large surface reservoirs result in compounds with octanol-air partition coefficients ( K OA ) larger than 10 5 being predominantly partitioned to indoor surface reservoirs, making them hard to be removed via ventilation. This result significantly impacts our understanding of VOC fate and human exposure in indoor environments. With such a large partitioning capacity, organic contaminants will have much longer indoor residence times than previously predicted.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.294
Teacher spread0.271 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2025
Admission routes2
Has abstractyes

Explore more

Same venueProceedings of the National Academy of SciencesSame topicIndoor Air Quality and Microbial ExposureFrench-language works237,207