Coincident evolution and functional adaptation of the taxonomically restricted genes <i>ivph-3</i> and <i>gon-14</i> in <i>Caenorhabditis</i> nematodes
Why this work is in the frame
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Bibliographic record
Abstract
Poorly conserved or taxonomically restricted genes represent a sizable portion of most genomes. Many of these genes participate in essential processes and can contribute to evolutionary innovation in species. Here, we evaluate two of the Caenorhabditis-restricted class of LIN-15B-domain-encoding genes, ivph-3 and gon-14, and compare their in vivo functions in two species, C. elegans and C. briggsae. We show that within the Elegans supergroup, ivph-3 and gon-14 exhibit sequence constraints distinct from other family members, including maintenance of a one-to-one orthology and a higher degree of sequence conservation. Coincidentally, mutants for either of the genes exhibit strong phenotypic defects that are similar within species (C. elegans or C. briggsae), but with notable differences when comparing between species. These findings highlight the genetic and genomic features associated with the evolution of a taxonomically restricted gene family.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it