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Record W4414523680 · doi:10.3389/fmed.2025.1665013

Case Report: Treatment of facial pyoderma gangrenosum with Upadacitinib

2025· article· en· W4414523680 on OpenAlex
Gai Ge, Li‐Rui Zhan, Meng Huang, Fei Su, Jinbo Chen, Jing Dong

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueFrontiers in Medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicAutoimmune and Inflammatory Disorders
Canadian institutionsInstitute of Infection and Immunity
Fundersnot available
KeywordsPyoderma gangrenosumPrednisoneNeutrophilic dermatosisPyodermaSkin lesion

Abstract

fetched live from OpenAlex

Pyoderma gangrenosum (PG) is a recurrent, painful, necrotizing ulcerative neutrophilic dermatosis. Facial PG (FPG) is a rare subtype of PG that is often misdiagnosed. A 20-year-old male with FPG showed improvement after treatment with a combination of prednisone and upadacitinib. Early diagnosis is crucial to avoid misdiagnosis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.569
Threshold uncertainty score0.537

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.277
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it