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Respiratory syncytial virus (RSV) vaccination recommendations in older adults

2025· article· en· W4414533538 on OpenAlex
Mohamed Toufic El Hussein

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenueThe Nurse Practitioner · 2025
Typearticle
Languageen
FieldMedicine
TopicRespiratory viral infections research
Canadian institutionsRockyview General HospitalUniversity of Alberta
Fundersnot available
KeywordsVaccinationImmunizationImmunosenescenceRespiratory tract infectionsOutbreakHealth careVirusRespiratory illnessRespiratory system

Abstract

fetched live from OpenAlex

ABSTRACT: Respiratory syncytial virus (RSV), first linked to severe respiratory illnesses (bronchiolitis or pneumonia) in infants and children, is now recognized as a serious problem in older adults. Since the 1970s, RSV outbreaks have been observed in various long-term care facilities housing older adults. Various studies highlighted that RSV is a major driver of illness in older adult community-dwelling populations. Recently, in Canada, three vaccines, Arexvy, Abrysvo, and mResvia, have been authorized for use in older adults to prevent RSV-related lower respiratory tract disease. The National Advisory Committee on Immunization (NACI) strongly recommends immunization programs for certain older adult populations, particularly those at an increased risk of severe RSV disease. Health care providers, including nurse practitioners (NPs), should discuss RSV vaccination with older adult patients due to their increased likelihood of comorbidities and age-related changes, such as immunosenescence and inflamm-aging, that increase their risk for severe disease. Monitoring of RSV vaccine efficacy and safety is ongoing. The purpose of this article is to inform NPs about the recent development of these vaccines, summarizing the safety and efficacy information and presenting a decision tree to help NPs make vaccine recommendations for nonpregnant adults.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.675
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.398
Teacher spread0.367 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it