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Record W4414564301 · doi:10.1212/ne9.0000000000200250

Education Research: Creating Online Interactive Case-Based Learning Experiences From Educational Case Reports With Large Language Models

2025· article· en· W4414564301 on OpenAlexaff
Christina Gao, Galina Gheihman, Tamara Kaplan, Liam G. McCoy, Luke Collins, Tara Wenzel, Ashley Paul, Haatem Reda, Laura Stein, Grace Kimbaris, Harry Sutherland-Foggio, Sybil Stacpoole, Tracey Milligan, Rudy Goh, Stephen Bacchi

Bibliographic record

VenueNeurology Education · 2025
Typearticle
Languageen
FieldMedicine
TopicClinical Reasoning and Diagnostic Skills
Canadian institutionsUniversity of Alberta
Fundersnot available
KeywordsFrontierEducational technologyNondeterministic algorithmInteractive LearningProcess (computing)Language acquisitionOnline learning

Abstract

fetched live from OpenAlex

Background and Objectives: into an interactive online format to facilitate case-based learning. Methods: were converted into a free-text "screenplay" using the LLM Claude 3.5 Sonnet. These "screenplays" were then delivered in an interactive format through an online platform using GPT-4o. Two neurology fellows interrogated (prompted) the cases delivered by the online platform in a question-and-answer manner, seeking history, examination findings, and investigation results to arrive at a diagnosis and plan. These neurology fellows were not aware of the case report or screenplay content and asked questions in a manner that they would when evaluating a patient. A neurologist then reviewed each question-and-answer exchange for "screenplay" adherence and medical appropriateness. Results were analyzed with descriptive statistics. Results: The overall number of appropriate responses generated by the LLM was 206 of 210 (98.1%). There were 26 of 210 responses in which additional content was generated, all of which were medically plausible or consistent with the context of the case. The 4 errors that occurred were omissions of investigation results at the "screenplay" stage, which are amenable to manual correction. The omissions were the results of 3 unrevealing blood tests and 1 electroencephalogram result. None of these errors precluded the establishment of the diagnosis and completion of the case. Discussion: into an interactive question-and-answer format using LLMs. It should be noted that the nondeterministic nature of frontier LLMs and the potential for such LLM versions to change frequently are relevant considerations in making estimates of performance. Further studies investigating the impacts of this educational innovation are required.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.022
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.450
Threshold uncertainty score0.986

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.022
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.438
Teacher spread0.398 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

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