The effects of intracranial stimulation on local neurovascular responses in humans
Bibliographic record
Abstract
BACKGROUND: Deep brain stimulation (DBS) is used to treat neurological and psychiatric disorders by modulating neuronal circuits. However, the effects of electrical stimulation on the neurovascular unit remain poorly understood due to limitations of capturing microvascular changes near implanted leads. This motivated us to investigate the cardioballistic waveform (CBW) as an electrophysiological surrogate of vascular dynamics in response to microstimulation. METHODS: Microelectrode recordings (n = 193; 108 patients) were obtained during DBS implantation surgery from two electrodes (∼600 μm apart) before and after microstimulation through one electrode. Generalized linear mixed models assessed CBW amplitude changes following 1 Hz or 100 Hz stimulation across basal ganglia regions and white matter. Neuronal activity was also analyzed, including phase-locking to the cardiac cycle, firing rates and patterns, and micro-LFP features. An analytical model interpreted CBW amplitudes as pressure-driven vessel wall expansion, enabling estimation of stimulation-evoked vasodilation and cerebral blood flow. RESULTS: CBW amplitudes increased significantly after 100 Hz stimulation at the stimulating electrode, but not at the non-stimulating electrode or after 1 Hz stimulation. Significant region-specific effects were observed in the ventral intermediate nucleus (Vim; 107 ± 13 %), subthalamic nucleus (STN; 79 ± 7 %), and globus pallidus internus (GPi; 78 ± 8 %), but not in white matter (WM; 50 ± 14 %) or substantia nigra pars reticulata (SNr; 45 ± 8 %). Across 50 recorded single units, 18 (36 %) were phase-locked to the cardiac cycle, but stimulation did not alter phase-locking value, and changes in spiking or micro-LFP features before versus after stimulation did not scale with CBW changes. Modelling showed that the mean 88 % CBW increase across Vim, STN, and GPi corresponds to an acute increase in cerebral blood flow. CONCLUSION: CBW recordings reveal that high-frequency DBS evokes region-specific vascular responses which can be modeled as substantial increases in local blood flow, establishing CBW amplitude as a potential biomarker of subcortical hemodynamics, and a potential therapeutic modality.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".