Spherical Gd<sub>3</sub>TaO<sub>7</sub> Particles with Phase-Stabilized Structure for Multimodal Bioimaging Application
Bibliographic record
Abstract
High Resolution Image Download MS PowerPoint Slide We report the polyol-mediated synthesis of spherical Gd 3 TaO 7 particles with controlled morphology, phase purity, and luminescence, engineered as trimodal nanoprobes for bioimaging. The method yields monodisperse particles (∼170 nm) that retain their spherical morphology even after high-temperature annealing at 800 and 1000 °C, overcoming the morphological instability and aggregation typically observed in tantalate-based systems. Structural characterization confirms the stabilization of the disordered cubic fluorite-related phase, with Eu 3+ ions acting as structural and luminescent probes. The doped particles exhibit broad-band red emission and long-lived excited states, suitable for optical detection. Notably, luminescence is significantly enhanced via postsynthetic coordination with 2-thenoyltrifluoroacetone (TTA), enabling clear intracellular visualization through confocal microscopy. In parallel, undoped Gd 3 TaO 7 particles show excellent performance as T 2 -weighted MRI contrast agents ( r 2 = 71.5 mM –1 s –1 at 7 T) and demonstrate strong X-ray attenuation for CT imaging, attributed to the presence of Gd and Ta high- Z elements. Confocal imaging confirms cellular uptake, while cytotoxicity assays in NIH-3T3 mouse fibroblasts demonstrate over 95% viability up to 1000 μg/mL, attesting to their biocompatibility. This work establishes Gd 3 TaO 7 -based nanoprobes as robust, compositionally engineered candidates for integrated MRI, CT, and optical imaging, with enhanced luminescence achievable via TTA sensitization for advanced bioimaging applications.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".