Zebrin II Expression in the Cerebellum of a Passerine Bird Species: Zebra Finch (Taeniopygia castanotis)
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
INTRODUCTION: Zebrin II (ZII) is a glycolytic enzyme that is expressed in cerebellar Purkinje cells. In both mammals and birds, ZII is expressed heterogeneously, such that there are sagittal stripes of Purkinje cells with a high ZII expression (ZII+) alternating with stripes of Purkinje cells with little or no expression (ZII-). To date, ZII expression studies examined at least one species from most of the major branches of the avian phylogeny including Paleognatha (tinamous, kiwi), Galloanseres (chicken), Columbaves (pigeon), and Elementaves (hummingbird). In this regard, the most glaring omission is that a species from Telluraves, a clade that contains 75% of all avian species, has not been studied. METHODS: In this paper, we examined ZII expression in the zebra finch Taeniopygia castanotis (order Passeriformes). Given that Telluraves have evolved sophisticated hindlimb movements associated with the jump to arboreality, we hypothesized that ZII expression would differ in those areas of the cerebellum that have a strong representation of the hindlimbs, namely folia II-V and IX. RESULTS: Contrary to our prediction, we found that the pattern of ZII expression in the cerebellum is highly similar to that observed in other bird species. In folium I, all Purkinje cells are ZII+. In the rest of the anterior lobe (folia II-V) there are 4 pairs of ZII+/- stripes. In the posterior lobe, folia VI-VII all Purkinje cells are ZII+, in folia VIII-IXcd there are 5-7 pairs of ZII+/- stripes, and in folium X all Purkinje cells are ZII+. Moreover, the expression of ZII+ in Purkinje cell terminals in the cerebellar and vestibular nuclei was similar to that observed in other species. CONCLUSION: These data indicate that the pattern of heterogeneous expression of ZII in cerebellar Purkinje is likely conserved across the entirety of the avian phylogenetic tree.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it