Recovery from immobilisation-associated osteoporosis with anti-resorptive and anabolic therapy
Bibliographic record
Abstract
The detrimental effects of immobilisation on bone health are well known and have been studied primarily in inpatient and long-term care settings. We describe a case seen in the osteoporosis clinic involving a patient with profound bone loss and hypercalcaemia secondary to chronic immobilisation in the setting of a debilitating systemic inflammatory myopathy. While undergoing treatment with bisphosphonate, her hypercalcaemia resolved, and no further bone loss was found based on bone turnover markers. Treatment of the underlying myopathy permitted significant recovery and return to ambulation, but with persistent very low bone density. To try to regain the lost bone mass, she was started on romosozumab. After 1 year of treatment, repeated measurements of bone mineral density showed an increase of 6% in her lumbar spine and 11% in her hip, respectively. Romosozumab use showed a significant recovery of nearly half of her original bone loss after her initial treatment with bisphosphonates.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".