Beyond the straight path: high-density laminar recordings in the ventral hippocampus with curved microprobes
Bibliographic record
Abstract
Neural circuits are organized within complex three-dimensional architectures. Most neural interfaces follow linear insertion trajectories, limiting their ability to achieve laminar recording in brain regions where neuronal layers lie approximately parallel to the insertion path. Here, we introduce a curved flexible neural interface that enables near-perpendicular alignment of the recording sites with the targeted neuronal layers. The device consists of a flexible Parylene-C neural probe, integrating 16 PEDOT:BF 4 -coated Au microelectrodes and a transient silk fibroin stiffener for controlled implantation. The electrodes exhibit low impedance at 1 kHz (29.2 ± 2.5 kΩ) and were accurately positioned across the layers of the ventral hippocampus using a rotational implantation strategy. Chronic in vivo recordings demonstrate stable electrochemical performance and reliable acquisition of local field potentials over four weeks. This work establishes a strategy for anatomically matched neural interfacing, enabling high-resolution investigation of neural circuits that are challenging to study with conventional linear probes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".