Haemostasis alterations in immune thrombocytopenia and their clinical significance
Bibliographic record
Abstract
Immune thrombocytopenia (ITP) is highly heterogeneous, and only a subset of patients with severe thrombocytopenia develops significant bleeding. ITP is also associated with a paradoxical increased risk of thrombosis. Here, we review the multiple haemostasis alterations reported in patients with ITP. Data show an increased platelet basal activation with lower platelet reactivity but with overall increased platelet function. The activated state of platelets and the endothelial dysfunction lead to an activation of coagulation. These alterations tend to counterbalance the bleeding tendency related to thrombocytopenia but have some variability among patients. Consequently, several functional assays have correlated the magnitude of haemostasis alterations to bleeding risk. These results suggest that ITP is a multifaceted bleeding disorder that goes beyond simple thrombocytopenia. The heterogeneity in the various alterations in haemostatic function is likely to drive the variable bleeding phenotypes observed. Haemostasis functional assays could thus serve as clinically relevant tools to individualize management.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.011 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.008 | 0.011 |
| Insufficient payload (model declined to judge) | 0.005 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".