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Record W4414990781 · doi:10.1101/2025.10.07.25337533

Multilevel associations between skills use, engagement, and treatment outcome in self-guided internet-delivered dialectical behavior therapy for substance use disorders

2025· preprint· en· W4414990781 on OpenAlexaff
Danielle Downie, Alexander R. Daros, Chelsey R. Wilks, Lena C. Quilty

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldPsychology
TopicDigital Mental Health Interventions
Canadian institutionsCentre for Addiction and Mental HealthUniversity of WindsorUniversity of Toronto
Fundersnot available
KeywordsMindfulnessMultilevel modelDialectical behavior therapySubstance useRandomized controlled trialSubstance abuseMultilevel modellingComorbidity

Abstract

fetched live from OpenAlex

Abstract Internet-delivered dialectical behavior therapy (iDBT) represents a scalable and accessible treatment approach for individuals with substance use disorders (SUDs), yet little is known about the mechanisms of change and the role of engagement in this format. This study examined within- and between-person associations between changes in skills-based constructs (mindfulness, DBT skills use, emotion dysregulation) and two treatment outcomes (SUD severity and functional disability) across a 12-week self-guided iDBT program. The moderating role of treatment engagement was also evaluated. 72 participants with past year SUDs were randomized to immediate or delayed iDBT and completed assessments at baseline and weeks 4, 8, and 12. Multilevel models were used to assess within- and between-person associations between skills and outcomes over time. Several indices of engagement were used including treatment acceptability, usability, and hours/days spent on iDBT. SUD severity and functional disability significantly decreased over the 12-week period. Within-person increases in emotion dysregulation were associated with higher SUD severity and disability, while higher levels of mindfulness between-persons were associated with lower disability. DBT skills were not significantly associated with outcomes. Greater within-person treatment acceptability (cognitive engagement) moderated reductions in SUD severity over time. Findings support the role of emotion dysregulation and mindfulness emerging as key correlates of treatment response. Treatment perceptions such as acceptability and usefulness may enhance outcomes, along with behavioural engagement. Future work should refine measurement of DBT skill acquisition and investigate longer-term functional impacts of digital DBT interventions. Author Summary In this study, we sought to understand potential mechanisms mechanisms of change in self-guided internet-delivered dialectical behavioural therapy (DBT) for individuals with substance use disorders. Using multilevel modeling, we evaluated the within- and between-person variation in three targets (mindfulness, DBT skills, and emotion dysregulation) over the treatment and follow-up period of 12 weeks and examined their association with treatment response (defined as substance use severity and functional disability). We then examined cognitive and behavioral facets of engagement as moderators of treatment response as well. With few DBT digital tools in existance, this study provides preliminary evidence that self-guided internet-delivered DBT tools can improve treatment targets similar to standard individual and group DBT formats. Overall, the study provides novel evidence on how several variables may enhance treatment outcome for individuals with substance use disorders, thereby informing future digital intervention trials.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.016

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.202
GPT teacher head0.447
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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