Embryological Determinants of Right Ventricular Morphogenesis in Pulmonary Atresia: The Role of Bipartite and Tripartite Configurations
Bibliographic record
Abstract
Pulmonary atresia is a complex congenital heart defect with marked morphological and clinical heterogeneity. Central to this variability is the embryological development of the right ventricle (RV) and its subcomponents. This review explores the embryological basis of RV development, emphasizing the bipartite and tripartite configurations and their clinical relevance in pulmonary atresia. Recent advances in human embryology, including high-resolution reconstructions from the Human Developmental Biology Resource (HDBR) and the work of Hikspoors and colleagues, provide an updated framework for understanding RV morphogenesis 1-2 . We highlight how disruption of ventricular partitioning, mural hypertrophy, and conotruncal malalignment contribute to the phenotypic spectrum of pulmonary atresia 3-4 . Finally, we examine the impact of RV morphology on surgical strategy and long-term prognosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".