Abnormal maximal tubular reabsorption of phosphate as a novel biomarker of physical dysfunction in older adults
Bibliographic record
Abstract
BACKGROUND: Physical dysfunction is a preclinical stage of disability in older adults, linked to severe adverse outcomes such as death and hospitalization. Maximal tubular reabsorption of phosphate (TmP/GFR), as a key biomarker of phosphate metabolism, may be related to physical dysfunction, but this relationship has not yet been explored. METHODS: Using data from the Rugao Longitudinal Ageing Study (RLAS), longitudinal logistic regression was employed to explore the relationship between abnormal TmP/GFR and physical dysfunction. For validation, the UK Biobank dataset was combined, and mendelian randomization (MR) was conducted to investigate causality. The maximal phosphate reabsorption was assessed using TmP/GFR, while physical dysfunction were evaluated through grip strength and the Timed Up and Go (TUG) test. RESULTS: During the four-year follow-up, 89 (13.55%) and 279 (40.85%) participants were identified as having a new onset of decreased grip and TUG. The abnormal TmP/GFR population had a significantly higher risk of decreased grip (OR 2.03, 95% CI 1.20-3.49) and decreased TUG (OR 1.49, 95% CI 1.05-2.12). MR analysis demonstrated the causal effect of TmP/GFR dysfunction population had significantly lower grip and lower walking speed. CONCLUSION: This study first identifies abnormal TmP/GFR as a novel biomarker of physical dysfunction in older adults. Additionally, its causal relationship further substantiates the reliability of this finding. Abnormal TmP/GFR enables early detection of physical dysfunction, facilitating the prevention of severe adverse outcomes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".