Drosophila blood cells bridge distant injury and gut homeostasis through Upd3-mediated inter-organ signaling
Bibliographic record
Abstract
Abstract Inter-organ communication is a central feature of host defence and tissue repair. In Drosophila , hemocytes secrete the cytokine-like ligand Unpaired 3 (Upd3, an IL-6 homolog) to activate JAK/STAT signaling in the gut, yet why this axis is essential for survival after injury has remained unclear. Here we show that loss of hemocyte activation by reactive oxygen species (ROS) and the consequent failure to produce Upd3 leads to adherens junction disruption, intestinal barrier dysfunction, and increased lethality following clean injury. Hemocyte-derived Upd3 drives sustained STAT activation in the gut epithelium, promoting enterocyte turnover and survival after injury. Chronic STAT activity further modulates intestinal stem cell fate and differentiation, indicating that hemocyte–gut signaling shapes long-term epithelial homeostasis. Notably, hemocytes home to the gut after distant wounding, where their localized presence enhances resistance to enteric infection. Taken together, these findings reveal that Drosophila blood cells bridge distant injury and gut homeostasis through Upd3-mediated inter-organ signaling that links wound sensing to epithelial integrity and host survival.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".