MIRIKIZUMAB – THE EFFICACY OF TREATMENT IN INFLAMMATORY BOWEL DISEASE
Bibliographic record
Abstract
Mirikizumab is a humanized monoclonal antibody directed against the p19 subunit of interleukin IL-23. In recent years, it has been the subject of numerous clinical trials as a potential new therapy for inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Additionally, mirikizumab has been evaluated in clinical trials as a possible treatment for plaque psoriasis. Clinical trial results in ulcerative colitis led to its approval in the European Union, the United States, Canada, and Japan for the treatment of adult patients with moderately to severely active disease. Despite promising clinical trial outcomes, mirikizumab has not yet been approved for the treatment of Crohn’s disease. This review focuses on summarizing findings from clinical trials investigating mirikizumab in inflammatory bowel diseases. The information is derived from scientific publications indexed in PubMed, searched using the terms “mirikizumab” and “IL-23” and published up to February 2025, as well as from published clinical trial results on mirikizumab.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".