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Record W4415237383 · doi:10.1101/2025.10.14.25338008

Delays in tuberculosis diagnosis and treatment in India: A patient journey analysis from Mumbai and Patna

2025· preprint· en· W4415237383 on OpenAlexafffund
Mohammad Abdullah Heel Kafi, Poshan Thapa, Madhukar Pai, Charity Oga‐Omenka

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldMedicine
TopicTuberculosis Research and Epidemiology
Canadian institutionsMcGill University Health CentreProvincial Health Services Authority
FundersMcGill University Health CentreMcGill University
KeywordsTuberculosisPandemicHealth carePrivate sectorPharmacyPublic healthTuberculosis diagnosisPublic sector

Abstract

fetched live from OpenAlex

ABSTRACT Background Tuberculosis (TB) patient services in India are often fragmented, undermining timely access to timely diagnosis and treatment. Understanding patient journeys is critical to strengthening TB care delivery and achieving elimination goals. Methods We conducted a cross-sectional study of 400 TB patients diagnosed between 2020– 2022 in two major Indian cities: Mumbai (n=200) and Patna (n=200). Using structured interviews, we examined health-seeking behavior, delays to diagnosis and treatment, the number and type of healthcare encounters, and out-of-pocket costs. Results Patients predominantly initiated care in the private sector (91% in Mumbai; 85% in Patna), often with pharmacies or private clinics. Care pathways were fragmented, requiring multiple provider visits before diagnosis. The median total delay from symptom onset to treatment initiation was 35 days (IQR: 13–81) in Patna and 26 days (IQR: 12–59) in Mumbai. Provider delays accounted for nearly 19 days in both settings. Patients made a median of 3 healthcare visits pre-diagnosis, with 23% experiencing ≥6 encounters. The financial burden of TB care was substantial, particularly in Mumbai, where consultation and diagnostic costs were markedly higher than in Patna. Longer delays and higher numbers of encounters were associated with being male, unemployed, having larger household size, and hesitation to seek care during the study period. Conclusion TB patient pathways in urban India pandemic were prolonged, costly, and fragmented — especially within the private sector during the COVID-19. Strengthening public-private integration, improving early diagnosis strategies, and protecting patients from financial hardship are essential priorities to accelerate TB elimination and strengthen health system resilience against future disruptions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.069
Threshold uncertainty score0.137

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.005
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.331
Teacher spread0.298 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

Explore more

Same venuemedRxiv→Same topicTuberculosis Research and Epidemiology→French-language works237,207→